Neural circuits are not hard-wired but modified throughout life based on experiences. When the delicate balance of plasticity is lost, the consequences may result in various disorders, including Alzheimer’s disease, Autism Spectrum Disorder (ASD) and Schizophrenia. The Marik lab at Pace University's Dyson College of Arts and Sciences aims to understand how disruption of certain proteins impact neural circuits and ultimately behavior. We are using a variety of techniques including molecular biology, microscopy, optogenetics, social behaviors, learning and memory tasks.

Autism Spectrum Disorder
Our research will provide better understanding on how mutations, in genes that increase risk for ASD, impact different cell types within the brain thereby altering complex behaviors. This will lead to a better understanding of how different cell types are impacted will lead to novel therapeutics to alleviate disruptions in neural plasticity.